The finger move, done by Zhang Yishan has been dubbed 'physically impossible' by stunned audience.
The actor raised his right hand, putting his little finger on top of his thumb while keeping the other three fingers straight.
The trick might seem easy, but many people said the difficulty is to keep the little finger on top of the thumb, not the other way around.
A topic page about the hand challenge was quickly set up on Weibo.
People flocked to upload pictures of themselves trying to pull off Zhang Yishan's hand trick. Some managed to do it, but others said it was impossible.
Li Sisi posted a picture on her Weibo account, which showed her interlocking her digits to form the shape of a knot.
Ms Li's followers immediately joined in and shared pictures of them taking on the challenge in the comments.
They said 'finger knot' was easier to achieve, however the catch was to do the trick with just one hand.
Medical experts, however, warned that people should not force themselves to hold these positions if they find them difficult.
According to Dr Jane Simmonds, a registered physiotherapist at University College London, those who could perform the difficult finger tricks are likely to have joint hypermobility, a common phenomenon present in 20 to 30 percent of the general population.
Dr Simmonds said: 'Joint hypermobility is more common in children and females.
'It is also more common in Asian and Afro Caribbean ethnic populations. This may account for one reason why finger tricks are popular in China.'
However, Dr Simmonds said for those who don't have joint hypermobility, attempting to perform the tricks could cause pain.
'It is not recommended to sustain or hold these stretched positions on the joints for extended periods of time as it may lead to joint and tissue irritation and pain.'
Mr Daniel Brown, a consultant hand surgeon at The Bone & Joint Centre at Spire Liverpool Hospital, said most people would not be able to perform the finger knot.
Mr Brown added: 'If people who don't have joint hypermobility try to do a finger knot, they are not likely to break their fingers, but it could cause them to stretch their ligaments and tendons, which could cause potential physical pain and may lead to instability of their joints and arthritis later in life.'
Mr Brown also said only 'a small number of people with unusual anatomy' could do the finger trick Chinese actor Zhang Yishan has performed.
Bizarre challenges involving different parts of body have always been popular among Chinese social media users.
In 2015, 130 million people joined in the so-called 'belly button challenge' as they tried to touch their navels by reaching around their backs. According to the organizer, the challenge was to test if the participants needed to lose weight.
In another popular challenges, women flaunted their figures by showing how many coins they could hold with their collarbones - and the rule was the more coins they could carry, the more beautiful they were.
Some other similar crazes have seen Chinese women trying to wrap banknotes around their wrists or to compare their waists with A4 paper to prove that they are skinny enough.
However, these trends have sparked concerns among medical experts, who claimed that the challenges were promoting a worrying concept of beauty among people, especially women.
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